Clinical Trials in which main indication is Progeria
Kire Stojkovski
PSI-CRO,Sofia,R.Bulgaria
Vesna Veslievska Stojkovska
University Clinic of Gynecology and Obstetrics, Medical Faculty Skopje
Evgenija Dameska-Stojkovska
UMBAL St Anna, Sofia R.Bulgaria
Vladimir Stojkovski
GOB 8 September, Skopje, Republic of N. Macedonia
Mihail Petrov Mihaylov
Skin Line, Sofia, R. Bulgaria
616-056.7:575.224.23
Abstract
Progeria is a disorder, known as progeroid syndrome, which is also known as Hutchinson-Gilford syndrome or Hutchinson-Gilford progeroid syndrome. A mutation on a single gene is causing this disease. The mutation that is causing it is on the LMNA (Lamina A) gene, the function of this gene is to make proteins that are needed to hold the nucleus cells together. The mutation is causing new protein called Progerin, which is causing the individuals who have this mutation to age faster than the persons who does not have this mutation. The people with this mutation looks a lot older than their actual age, and in most cases live until late-teen years or some of the persons with this mutation live up until early twenties. Usually there are cardiovascular problems with severe grading, starting to develop in the puberty of the people with these syndromes. In later stages these complications lead to death of the patients with Progeria.
Keywords: Key Words: Progeria, Progerin, Hutchinson-Gilford Syndrome, LMNA, Gene mutation
ISSN 2955-2117
EISSN 2955-2133
Journal DOI https://www.doi.org/10.59710/oaijoaru
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Publisher: Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia
E-mail: oaijar.universes@gmail.com oaijar.universes@outlook.com