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UNIVERSES
ISSN 2955-2117
EISSN 2955-2133
Journal DOI https://www.doi.org/10.59710/oaijoaru

Clinical Trials in which main indication is Progeria

Kire Stojkovski

PSI-CRO,Sofia,R.Bulgaria

Vesna Veslievska Stojkovska

University Clinic of Gynecology and Obstetrics, Medical Faculty Skopje

Evgenija Dameska-Stojkovska

UMBAL St Anna, Sofia R.Bulgaria

Vladimir Stojkovski

GOB 8 September, Skopje, Republic of N. Macedonia

Mihail Petrov Mihaylov

Skin Line, Sofia, R. Bulgaria

UDC:

616-056.7:575.224.23

pp. 7-10 in OAIJARU Vol.3 No. 1

Abstract

Progeria is a disorder, known as progeroid syndrome, which is also known as Hutchinson-Gilford syndrome or Hutchinson-Gilford progeroid syndrome. A mutation on a single gene is causing this disease. The mutation that is causing it is on the LMNA (Lamina A) gene, the function of this gene is to make proteins that are needed to hold the nucleus cells together. The mutation is causing new protein called Progerin, which is causing the individuals who have this mutation to age faster than the persons who does not have this mutation. The people with this mutation looks a lot older than their actual age, and in most cases live until late-teen years or some of the persons with this mutation live up until early twenties. Usually there are cardiovascular problems with severe grading, starting to develop in the puberty of the people with these syndromes. In later stages these complications lead to death of the patients with Progeria.

Keywords: Key Words: Progeria, Progerin, Hutchinson-Gilford Syndrome, LMNA, Gene mutation

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ISSN 2955-2117
EISSN 2955-2133
Journal DOI https://www.doi.org/10.59710/oaijoaru
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Publisher: Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia

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